Sally Zhang is a junior who is majoring in Biology. She was awarded a Fall 2018 Independent Grant which she used to conduct research on ubiquination and Alzheimer's disease under Dr. Hyojung Choo. I started doing my project at the Seyfried Lab of the Biochemistry department and Center for Neurodegenerative diseases of Emory School of Medicine in April 2018. My project aims to examine the mechanisms underlying the turnover of insoluble neurofibrillary tangles of Tau, a key type of pathological protein aggregate in Alzheimer’s disease. Alzheimer’s disease is characterized by the presence of protein aggregates and a loss of protein homeostasis. Ubiquitin (Ub) is a 76 amino acid peptide that marks proteins for degradation mainly through the ubiquitin-proteasome system (UPS) and autophagy. Modification by Lys-48-linked poly-Ub chains has been reported as means of selecting proteins for degradation by the UPS. Whereas, Lys-63-linked poly-ubiquitination is associ...